Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues

J Med Chem. 1982 Oct;25(10):1120-2. doi: 10.1021/jm00352a002.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Enzymes / metabolism
  • Escherichia coli / enzymology
  • Folic Acid Antagonists*
  • Methotrexate / pharmacology
  • Models, Molecular
  • Molecular Conformation
  • Receptors, Drug
  • Trimethoprim / analogs & derivatives*
  • Trimethoprim / pharmacology
  • X-Ray Diffraction

Substances

  • Enzymes
  • Folic Acid Antagonists
  • Receptors, Drug
  • Trimethoprim
  • Methotrexate